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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Resveratrol, Rapamycin
Phytochemical Name Resveratrol (PubChem CID: 445154 )
Anticancer drug Name Rapamycin (PubChem CID: 5284616 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 378
Ref_1
Pair Name Resveratrol, Rapamycin
Disease Info [ICD-11: 2D10.1] Papillary thyroid cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL-xL hsa598
Up-regulation Expression CASP3 hsa836
Up-regulation Expression CASP8 hsa841
Up-regulation Expression CASP9 hsa842
Down-regulation Expression MCL1 hsa4170
Down-regulation Phosphorylation RPS6KB1 hsa6198
In Vitro Model KTC-1 Poorly differentiated thyroid gland carcinoma Homo sapiens (Human) CVCL_6300
TPC-1 Thyroid gland papillary carcinoma Homo sapiens (Human) CVCL_6298
In Vivo Model KTC-1 and TPC-1 cells in logarithmic growth phase were subcutaneously inoculated into the right armpit of nude mice (5×10⁶ cells/mouse).
Result The present study suggests that the combination of rapamycin and resveratrol may be a promising strategy for the treatment of papillary thyroid cancer.
03. Reference
No. Title Href
1 Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. Arch Biochem Biophys. 2020 Aug 15;689:108461. doi: 10.1016/j.abb.2020.108461. Click
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